Influence of Estrogen on the Electrolyte Pattern of the Immature Rat Uterus*
نویسنده
چکیده
The present paper reports measurements on the electrolyte content of immature rat uteri before and after the administration of a single dose of estrogen. It has been shown previously that estrogen causes a prompt and striking increase in the weight and water content of rat uteri and that these changes are followed by a further gain in weight associated with an increase in mitotic activity and protoplasmic growth (1). It is to be expected that there should be shifts in the electrolytes to correspond with the ebb and flow of water. If this thesis is correct, these phenomena should offer an unusual opportunity to study the effect of estzogen on electrolytes and to investigate electrolyte metabolism during normal protoplasmic growth. Furthermore, the pattern of t,he electrolytes gives some information concerning the location of the water which is responsible for t,he increase in uterine weight. The data obtained show that estrogen causes a significant increase in the sodium, chloride, and calcium content of the uterus during the period of edema and later, during the period of protoplasmic growth, an increase in potassium, phosphorus, and magnesium content. At the period of greatest edema (6 hours after estrogen administration), the electrolyte pattern differs considerably from that of untreated controls. The pattern suggests that the edema is both extracellular and intracellular. At the peak of uterine growth (30 hours after estrogen administration), the
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